{"product_id":"aurizon-ear-drops-for-dogs-10ml","title":"Aurizon ear drops for dogs 10ml \/ gocce auricolari per cani","description":"\u003cp\u003e  \u003c\/p\u003e\n\u003cp\u003e1 ml AURIZON contains:\u003c\/p\u003e\n\u003cp\u003eMarbofloxacin 3 mg,\u003cbr\u003eClotrimazole Ph. Eur 10 mg,\u003cbr\u003eDexamethasone acetate 1.0 mg,\u003cbr\u003e(equivalent to dexamethasone 0.9 mg).\u003cbr\u003eList of excipients: Propyl gallate (E 310), Sorbitan oleate, Silica, colloidal anhydrous, Medium chain triglycerides.\u003cbr\u003eIt does not contain antimicrobial preservatives.\u003cbr\u003e \u003c\/p\u003e\n\u003cp\u003ePharmacological properties:\u003cbr\u003eMarbofloxacin, a synthetic bactericidal agent that belongs to the fluoroquinolone family and acts as a DNA gyrase inhibitor. It presents a wide spectrum of actions against Gram-positive (ex. Staphylococcus intermedius) and Gram-negative (Pseudomonas aeruginosa, Escherichia coli and Proteus mirabilis) bacteria.\u003cbr\u003eClotrimazole, an anti-fungal agent that belongs to the imidazole family and causes changes in membrane permeability, allowing intracellular components to diffuse into the extracellular space, stopping cellular molecular synthesis. It presents a wide spectrum, especially against Malassezia pachydermatis.\u003cbr\u003eDexamethasone acetate, synthetic glucocorticoid with anti-inflammatory and antipruritic action.\u003c\/p\u003e\n\u003cp\u003ePharmacokinetic properties:\u003cbr\u003ePharmacokinetic studies in dogs, regarding therapeutic doses, showed the following:\u003cbr\u003e- The maximum concentrations of marbofloxacin in the plasma reach up to 0.06 μg\/ml on the 14th day of treatment.\u003cbr\u003e- Marbofloxacin binds weakly to plasma proteins (\u0026lt;10% in dogs) and is eliminated slowly, especially in the active form, approximately 2\/3 in the urine and 1\/3 in the feces. Absorption of clotrimazole is very poor (plasma concentration - The plasma concentration of dexamethasone acetate reaches 1.25 ng\/ml on the 14th day of treatment.\u003cbr\u003e- Dexamethasone resorption is not increased by the inflammatory process induced by otitis.\u003c\/p\u003e\n\u003cp\u003eTarget species:\u003cbr\u003eDogs.\u003c\/p\u003e\n\u003cp\u003eIndications:\u003cbr\u003eIn dogs: treatment of otitis externa of bacterial or fungal origin - respectively caused by bacteria sensitive to marbofloxacin and fungi sensitive to clotrimazole, especially Malassezia pachydermatis. The product should be used based on sensitivity tests.\u003c\/p\u003e\n\u003cp\u003eContraindications:\u003cbr\u003eDo not administer to dogs with a perforated tympanic membrane. Do not administer to dogs with known hypersensitivity to any of the ingredients. Do not administer to pregnant or lactating females.\u003c\/p\u003e\n\u003cp\u003eAdverse effects:\u003cbr\u003eAdverse reactions usually associated with corticosteroid drugs may occur (changes in biochemical and hematological parameters, such as increased alkaline phosphatase and aminotransferase, neutrophilia). Prolonged and intensive use of topical corticosteroid preparations usually results in local and systemic effects, including suppression of adrenal gland function, thickening of the epidermis, and delayed wound healing. In rare cases, the use of this medicine has led to a decrease in hearing acuity, especially in elderly dogs, and in most cases it is transient.\u003cbr\u003eSpecial precautions for use in animals:\u003cbr\u003eLong-term use of a single class of antibiotics can induce resistance in a bacterial population. The use of fluoroquinolones is recommended in the treatment of clinical conditions that have responded poorly or are expected to respond poorly to other classes of antibiotics.\u003cbr\u003eThe external ear canal must be carefully cleaned and dried before treatment.\u003cbr\u003eBefore using the product as a treatment, the integrity of the tympanic membrane must be checked.\u003cbr\u003eAvoid any kind of contamination during use.\u003c\/p\u003e","brand":"Vetoquinol","offers":[{"title":"Default Title","offer_id":37943937761447,"sku":"","price":29.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0476\/3261\/3543\/products\/aurizon__96224__51792.jpg?v=1613402007","url":"https:\/\/www.petshopluna.com\/products\/aurizon-ear-drops-for-dogs-10ml","provider":"Pet Shop Maya","version":"1.0","type":"link"}