{"product_id":"amoxineovit-c-100cp-oxytetracycline-chickens-and-dogs-pollame-e-cani","title":"AMOXINEOVIT C 100cp \/\/ OXYTETRACYCLINE \/\/ chickens and dogs \/ Pollame e cani","description":"\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eCOMPOSITION\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOxytetracycline hydrochloride 12 mg\/cpr., amoxicillin trihydrate 9.6 mg\/cpr., neomycin sulfate 9.6 mg\/cpr.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eDirections\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe product is recommended for chickens and dogs in the treatment of bacterial infections caused by germs sensitive to the active substances such as:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan\u003ein chickens\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e – colibacillary, pasteurellal, staphylococcal, streptococcal, salmonella (pullorosis) infections, anaerobic enterotoxemias.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan\u003ein dogs\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e – colibacillary enteritis, salmonella infections, respiratory infections (kennel cough – \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eBordetella bronchiseptica\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e ), clostridiosis.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eCONTRAINDICATIONS\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDo not administer in case of hypersensitivity to the active substances or any of the excipients.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eADVERSE REACTIONS\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThey don't know each other.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIf you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eTARGET SPECIES\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eChickens and dogs.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eDOSAGE FOR EACH SPECIES, ROUTE AND METHOD OF ADMINISTRATION\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe product is administered individually, orally, in the following doses:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan\u003ein chickens\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e : the dose is 1 tablet per kg of body weight per day, for 5 - 7 consecutive days.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan\u003ein dogs:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e administer 1 tablet\/1.5 kg body weight per day, for 7 consecutive days\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eTo ensure correct dosing, body weight should be determined as accurately as possible to avoid underdosing.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eRECOMMENDATIONS ON CORRECT ADMINISTRATION\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOxytetracycline, amoxicillin, and neomycin should be used only based on susceptibility testing, whenever possible.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWAITING TIME\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMeat: 28 days.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDo not administer during the laying period to hens whose eggs are used for consumption.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eSPECIAL STORAGE PRECAUTIONS\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eKeep out of reach of children.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eStore below 25ºC, in the original packaging.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDo not use after the expiry date stated on the label.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eShelf life of the veterinary medicinal product after first opening the immediate packaging: 6 months.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eSPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED VETERINARY MEDICINAL PRODUCTS OR WASTE MATERIALS, IF ANY\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMedicines should not be thrown away in wastewater or household waste.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAsk your veterinarian for information on how to dispose of medicines no longer required. These measures help protect the environment.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eOTHER INFORMATION\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003ePharmacodynamic properties\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan\u003eOxytetracycline hydrochloride\u003c\/span\u003e\u003c\/em\u003e\u003c\/strong\u003e\u003cspan\u003e is part of the group of synthetic tetracyclines and has almost exclusively bacteriostatic action with a broad spectrum, being used to treat infections caused by gram-positive bacteria (\u003c\/span\u003e\u003cem\u003e\u003cspan\u003e Staphylococci, Streptococci, Actinomyces sp., Bacillus anthracis, Clostridium perfringens, Clostridium tetani, Listeria monocytogenes\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e ) and gram-negative bacteria (\u003c\/span\u003e\u003cem\u003e\u003cspan\u003e Chlamydia, Rickettsia\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e ) sensitive to oxytetracycline, being also effective against protozoa. The penetration of oxytetracycline into susceptible microorganisms is mediated by transport proteins unique to the bacterial inner cytoplasmic membrane. The binding of the drug to the 30S subunit of the bacterial ribosome probably blocks the access of aminoacyl-tRNA to the mRNA-ribosome complex at the level of the acceptor site, as a result of which the growth of the peptide chain is stopped, respectively the synthesis of bacterial proteins is prevented.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan\u003eAmoxicillin trihydrate\u003c\/span\u003e\u003c\/em\u003e\u003c\/strong\u003e\u003cspan\u003e is an aminopenicillin with low toxicity and an antimicrobial spectrum similar to ampicillin. It has a strong bactericidal action on Gram-negative bacteria (\u003c\/span\u003e\u003cem\u003e\u003cspan\u003e Actinobacillus, Bordetella, Escherichia, Haemophilus, Pasteurella, Salmonella,\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e etc.) and Gram-positive bacteria (\u003c\/span\u003e\u003cem\u003e\u003cspan\u003e B. Anthracis, Clostridium, Actinomyces, Erysipelotrix,\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e etc.). Amoxicillin, having a structure similar to D-alanyl-D-alamine, competes with this substance and couples with murein-transpeptidase, an enzyme necessary for the synthesis of N-acetyl-muramic acid, which constitutes the supporting skeleton of the microbial membrane, as a result of which amoxicillin blocks the synthesis of mucopeptides in the microbial wall. Bacteria become giants, the pressure inside the bacteria increases and it disintegrates.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan\u003eNeomycin sulfate\u003c\/span\u003e\u003c\/em\u003e\u003c\/strong\u003e\u003cspan\u003e is part of the group of aminoglycoside antibiotics, showing similarities to some polysaccharides in the capsule and wall of bacterial cells. Neomycin is a first-generation aminoglycoside, comprising in the molecule three aminosugars linked to an aminocyclitol. Aminoglycosides are active especially against aerobic gram-negative bacilli:\u003c\/span\u003e\u003cem\u003e\u003cspan\u003e Enterobacter, E. coli, Klebsiella pneumoniae, Proteus mirabilis, Salmonella.\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e Neomycin acts bactericidal, penetrating bacterial cells by active transport and diffusion. Inside the cells, aminoglycoside molecules bind to bacterial 30S ribosomal subunits, which results in inhibition of protein synthesis by preventing the initiation of peptide formation, by misreading the genetic code and by breaking up polysomes into non-functional monosomes.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003ePharmacokinetic properties\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan\u003eOxytetracycline hydrochloride\u003c\/span\u003e\u003c\/em\u003e\u003c\/strong\u003e\u003cem\u003e\u003cspan\u003e is\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e absorbed in the stomach, duodenum and the first part of the small intestine, but the absorption process is reduced in case of gastric hypoacidity and by the presence of food, especially dairy products, as well as by drugs containing calcium, magnesium and iron, with which they form non-absorbable chelates. The plasma half-life is relatively short, namely 10-11 hours, the binding to plasma proteins being 65%. Concentrations in the cerebrospinal fluid are low, ineffective when administered orally. The highest levels are achieved in bile, where concentrations reach values ​​5-30 times higher than in plasma. Part of the molecules eliminated in the intestine with bile are reabsorbed, entering the enterohepatic circulation. About 40% is eliminated through the stool, which explains the marked influence of the intestinal flora. Renal elimination, by glomerular filtration, concerns approximately 60% of the active form.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan\u003eAmoxicillin trihydrate\u003c\/span\u003e\u003c\/em\u003e\u003c\/strong\u003e\u003cspan\u003e is resistant to hydrochloric acid and is well absorbed from the intestine, with 93% of the orally administered dose reaching the circulation. Amoxicillin is eliminated from the body mainly by renal mechanisms, with 90% by tubular secretion. Other minor excretion routes are the biliary tract and milk. Part of the antibiotic is metabolized by hydrolysis to penicilloic acid (inactive), which is then eliminated in the urine. The half-life is 90 minutes in cattle, and the plasma clearance is 1.9 ml\/kg\/min in canines.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan\u003eNeomycin sulfate\u003c\/span\u003e\u003c\/em\u003e\u003c\/strong\u003e\u003cspan\u003e administered orally is absorbed to a small extent (about 30%), the action being limited to the intestine. It is indicated in digestive infections with sensitive germs. Administered orally, in high doses, for a long time, it can cause the development of a\u003c\/span\u003e\u003cem\u003e\u003cspan\u003e malabsorption syndrome\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e of moderate intensity, with diarrhea. The phenomenon is attributed to morphological changes in the intestinal villi, the precipitation of bile salts, the inhibition of the activity of pancreatic lipase and intestinal lactase, so occasionally neomycin administered orally can be the cause of intestinal dysbacteriosis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eCOMPOSIZIONE\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOssitetraciclina cloridrato 12 mg\/cpr., amoxicillina triidrato 9,6 mg\/cpr., neomicina solfato 9,6 mg\/cpr.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eIndicazioni\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIl prodotto è consigliato per polli e cani nel trattamento delle infezioni batteriche causate da germi sensibili ai principi attivi quali:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan\u003enei polli\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e – infezioni da colibacilliche, pasteurelliche, stafilococco, streptococco, salmonella (pulorosi), enterotossimie anaerobiche.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan\u003enei cani\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e – enterite colibacillare, infezioni da salmonella, infezioni respiratorie (tosse dei canili – \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eBordetella bronchiseptica\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e ), clostridiosi.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eCONTROINDICAZIONI\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNon somministrare in caso di ipersensibilità ai principi attivi o ad uno qualsiasi degli eccipienti.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eREAZIONI AVVERSE\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNon si conoscono.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSe notate reazioni gravi o altri effetti non menzionati in questo foglio illustrativo, informate il vostro veterinario.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eSPECIE DI DESTINAZIONE\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePolli e cani.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eDOSI PER CIASCUNA SPECIE, VIA E MODALITÀ DI SOMMINISTRAZIONE\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIl prodotto viene somministrato singolarmente, per via orale nelle seguenti dosi:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan\u003eper i polli\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e : la dose è di 1 compressa per kg di massa corporea al giorno, per 5 - 7 giorni consecutivi.\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003e\u003cspan\u003enel cane:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e somministrare 1 compressa\/1,5 kg di massa corporea al giorno, per 7 giorni consecutivi\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003ePer garantire un dosaggio corretto, la massa corporea deve essere determinata il più fedelmente possibile per evitare un sottodosaggio.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eRACCOMANDAZIONI RIGUARDANTI LA CORRETTA AMMINISTRAZIONE\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOssitetraciclina, amoxicillina e neomicina devono essere utilizzate solo sulla base di test di sensibilità, quando possibile.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eTEMPO DI ATTESA\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCarne: 28 giorni.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNon viene somministrato durante il periodo di deposizione alle galline le cui uova vengono utilizzate per il consumo.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003ePRECAUZIONI PARTICOLARI PER LA CONSERVAZIONE\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eTenere fuori dalla portata dei bambini.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eConservare a temperatura inferiore a 25 ºC, nella confezione originale.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNon utilizzare dopo la data di scadenza riportata sull'etichetta.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePeriodo di validità del medicinale veterinario dopo la prima apertura del confezionamento primario: 6 mesi.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003ePRECAUZIONI PARTICOLARI PER LO SMALTIMENTO DEL MEDICINALE VETERINARIO NON UTILIZZATO O DEI RIFIUTI, COME NECESSARIO\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eI medicinali non devono essere gettati nelle acque reflue o nei rifiuti domestici.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eChiedi al tuo veterinario informazioni su come smaltire i farmaci che non servono più. Queste misure contribuiscono alla protezione dell’ambiente.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eALTRE INFORMAZIONI\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eProprietà farmacodinamiche\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan\u003eL'ossitetraciclina cloridrato\u003c\/span\u003e\u003c\/em\u003e\u003c\/strong\u003e\u003cspan\u003e fa parte del gruppo delle tetracicline sintetiche ed esplica un'azione batteriostatica quasi esclusivamente ad ampio spettro, essendo utilizzata per trattare le infezioni causate da batteri gram-positivi (\u003c\/span\u003e\u003cem\u003e\u003cspan\u003e Stafilococchi, Streptococchi, Actinomyces sp., Bacillus anthracis, Clostridium perfrigens, Clostridium tetani, Listeria monocytogenes\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e ) e gram negativi (\u003c\/span\u003e\u003cem\u003e\u003cspan\u003e Chlamydia, Rickettsia\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e ) sensibili all'ossitetraciclina, essendo efficaci anche contro i protozoi. La penetrazione dell'ossitetraciclina nei microrganismi sensibili è mediata da proteine ​​trasportatrici esclusive della membrana citoplasmatica interna dei batteri. Il legame del farmaco alla subunità 30S del ribosoma batterico probabilmente blocca l’accesso dell’aminoacil-tRNA al complesso mRNA-ribosoma a livello del sito accettore, di conseguenza viene arrestata la crescita della catena peptidica, rispettivamente la la sintesi delle proteine ​​batteriche è impedita.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan\u003eL'amoxicillina triidrato\u003c\/span\u003e\u003c\/em\u003e\u003c\/strong\u003e\u003cspan\u003e è un'aminopenicillina con tossicità ridotta e uno spettro antimicrobico simile all'ampicillina. Ha una forte azione battericida sui batteri Gram-negativi (\u003c\/span\u003e\u003cem\u003e\u003cspan\u003e Actinobacillus, Bordetella, Escherichia, Haemophilus, Pasteurella, Salmonella\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e , ecc.) e sui batteri Gram-positivi (\u003c\/span\u003e\u003cem\u003e\u003cspan\u003e B. Anthracis, Clostridium, Actinomyces, Erysipelotrix,\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e ecc.). L'amoxicillina, avendo una struttura simile alla D-alanil-D-alamina, compete con questa sostanza e si accoppia con la mureina-transpeptidasi, enzima necessario per la sintesi dell'acido N-acetil-muramico, che costituisce lo scheletro di sostegno della membrana microbica, di conseguenza l'amoxicillina blocca la sintesi dei mucopeptidi nella parete microbica. I batteri diventano giganteschi, la pressione all'interno del batterio aumenta e questo si disintegra.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan\u003eLa neomicina solfato\u003c\/span\u003e\u003c\/em\u003e\u003c\/strong\u003e\u003cspan\u003e fa parte del gruppo degli antibiotici aminoglicosidici e mostra somiglianze con alcuni polisaccaridi nella capsula e nella parete delle cellule batteriche. La neomicina è un aminoglicoside di prima generazione, comprendente tre aminozuccheri legati ad un aminociclitolo nella molecola. Gli aminoglicosidi sono particolarmente attivi contro i bacilli aerobi gram-negativi:\u003c\/span\u003e\u003cem\u003e\u003cspan\u003e Enterobacter, E. coli, Klebsiella pneumoniae, Proteus mirabilis, Salmonella.\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e La neomicina agisce battericida entrando nelle cellule batteriche mediante trasporto e diffusione attivi. All'interno delle cellule, le molecole di aminoglicosidi si legano alle subunità ribosomiali 30S batteriche, determinando l'inibizione della sintesi proteica impedendo l'inizio della formazione di peptidi, interpretando erroneamente il codice genetico e scomponendo i polisomi in monosomi non funzionali.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eProprietà farmacocinetiche\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan\u003eL'ossitetraciclina cloridrato\u003c\/span\u003e\u003c\/em\u003e\u003c\/strong\u003e\u003cem\u003e\u003cspan\u003e viene\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e assorbita nello stomaco, nel duodeno e nella prima parte dell'intestino tenue, ma il processo di assorbimento è ridotto in caso di ipoacidità gastrica e in presenza di alimenti, soprattutto latticini, nonché di farmaci contenenti calcio, magnesio e ferro, con cui formano chelati non assorbibili. L’emivita plasmatica è relativamente breve, ovvero 10-11 ore, il legame con le proteine ​​plasmatiche è pari al 65%. Le concentrazioni di liquido cerebrospinale sono basse, inefficaci se somministrate per via orale. I livelli più elevati si raggiungono nella bile, dove le concentrazioni raggiungono valori 5-30 volte superiori a quelle plasmatiche. Parte delle molecole eliminate nell'intestino con la bile vengono riassorbite, entrando nel circolo enteroepatico. Circa il 40% viene eliminato attraverso le feci, il che spiega la marcata influenza della flora intestinale. L'eliminazione renale, attraverso filtrazione glomerulare, rappresenta circa il 60% della forma attiva.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan\u003eL'amoxicillina triidrato\u003c\/span\u003e\u003c\/em\u003e\u003c\/strong\u003e\u003cspan\u003e è resistente all'acido cloridrico ed è ben assorbita dall'intestino, ovvero il 93% della dose somministrata per via orale raggiunge la circolazione. L’amoxicillina viene eliminata dall’organismo principalmente attraverso meccanismi renali, rispettivamente per il 90% mediante secrezione tubulare. Altre vie minori di escrezione sono le biliari e il latte. Parte dell'antibiotico viene metabolizzata mediante idrolisi ad acido penicilloico (inattivo), che viene poi escreto nelle urine. L'emivita è di 90 minuti nei bovini e la clearance plasmatica è di 1,9 ml\/kg\/min nei canidi.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003e\u003cspan\u003eLa neomicina solfato\u003c\/span\u003e\u003c\/em\u003e\u003c\/strong\u003e\u003cspan\u003e somministrata per via orale viene assorbita in piccola misura (circa il 30%), essendo l'azione limitata all'intestino. È indicato nelle infezioni digestive con germi sensibili. Somministrato per via orale, in dosi elevate, per lungo tempo, può provocare lo sviluppo di una\u003c\/span\u003e\u003cem\u003e\u003cspan\u003e sindrome da malassorbimento\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e di moderata intensità, con diarrea. Il fenomeno viene attribuito ad alcune alterazioni morfologiche a livello dei villi intestinali, precipitazione dei sali biliari, inibizione dell'attività della lipasi pancreatica e della lattasi intestinale, per cui occasionalmente la neomicina somministrata per via orale può essere causa di disbatteriosi intestinale.\u003c\/span\u003e\u003c\/p\u003e","brand":"Romvac","offers":[{"title":"Default Title","offer_id":49951839027547,"sku":"","price":14.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0476\/3261\/3543\/files\/amoxineovit-c.jpg?v=1737800813","url":"https:\/\/www.petshopluna.com\/products\/amoxineovit-c-100cp-oxytetracycline-chickens-and-dogs-pollame-e-cani","provider":"Pet Shop Maya","version":"1.0","type":"link"}