{"product_id":"eprecis-inj-100ml-eprinomectin-for-cows-per-bovini","title":"EPRECIS INJ. 100ML \/ EPRINOMECTIN - for cows, goats, sheep \/ per bovini, caprini, ovini","description":"\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eCOMPOSITION\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e1 ml of product contains:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eActive substance:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eEprinomectin 20 mg\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eExcipient(s):\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eButylhydroxytoluene (E321) 0.8 mg\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003ePHARMACEUTICAL FORM\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSolution for injection. Clear colourless to pale yellow solution.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eTARGET SPECIES\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCattle, goats, sheep\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003ePHARMACODYNAMIC PROPERTIES\u003c\/span\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eEprinomectin is a member of the macrocyclic lactone class of endectocides. The compounds of this class bind selectively with high affinity to chloride ion channels in muscle and nerve cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the muscle or nerve cells resulting in paralysis and death of the parasite. Compounds of this class may also interact with other chloride ion channels, such as those linked to the neurotransmitter gamma-aminobutyric acid (GABA). The safety margin of compounds of this class is due to the fact that mammals do not have glutamate chloride ion channels and macrocyclic lactones have a low affinity for other mammalian chloride ion channels, which is why they do not cross the blood-brain barrier.\u003c\/span\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003ePHARMACOKINETICS\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAbsorption\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eFollowing subcutaneous administration, the bioavailability of eprinomectin is approximately 89%. Maximum plasma concentration of 58 μg\/L was reached after 36-48 hours.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003edistribution\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThere is a linear relationship between the administered dose and the observed plasma concentration at therapeutic doses between 0.1 and 0.4 mg\/kg. Eprinomectin has a high affinity (greater than 99%) for bovine plasma proteins.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eMetabolism\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eEprinomectin is not extensively metabolized in cattle. The metabolites of the molecule reach approximately 10% of the total residues in plasma, milk, edible tissues and feces.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eElimination\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eEprinomectin has a half-life of 65-75 hours and the main route of elimination is through the feces.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eEnvironmental properties\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eLike other macrocyclic lactones, eprinomectin may adversely affect other organisms that are not normally targeted by it. After treatment, excretion of potentially toxic levels of eprinomectin may take several weeks. Faeces containing eprinomectin excreted on pasture by treated animals may reduce the abundance of dung fauna which may affect its degradation. Eprinomectin is very toxic to aquatic organisms, persists in soil and may accumulate in sediments.\u003c\/span\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eHOW TO USE\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eTreatment of infestations with the following ectoparasites and endoparasites sensitive to eprinomectin:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOstertagia ostertagi\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOstertagia lyrata\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOstertagia spp.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCooperia oncophora\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCooperia pectinata\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSurnabada Cooperative\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDotted cooperation\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCooperia spp.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eHaemonchus placei\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eTrichostrongylus axis\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eTrichostrongylus colubriformis\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eTrichostrongylus spp.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eBunostomum phlebotomum\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eNematodirus helvetianus\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOesophagostomum radiatum\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOesophagostomum spp.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eTrichuris spp.\u003c\/span\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eLungworms:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDictyocaulus viviparous\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eBlood-sucking lice:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eHaematopinus eurysternus, Linognathus vituli, Solenopotes capillatus\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eHorn flies:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eHaematobia irritans\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eInsect larvae (parasitic stage):\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eHypoderma bovis, Hypoderma lineatum\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eMites:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSarcoptes scabiei var. bovis\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003ePREVENTING INFESTATIONS\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe product protects treated animals against reinfestations with: Trichostrongylus spp. (including Trichostrongylus axei and Trichostrongylus colubriformis), Haemonchus placei, Cooperia spp. (including Cooperia oncophora, Cooperia punctata, Cooperia surnabada), Dictyocaulus viviparus, Oesophagostomum radiatum, Ostertagia spp. (including Ostertagia ostertagi and Ostertagia lyrata) and Nematodirus helvetianus for 14 days and Haematobia irritans for at least 7 days.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eCAUTION\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe following practices should be avoided as they increase the risk of developing resistance and ultimately lead to treatment ineffectiveness:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eFrequent and repeated use of antiparasitics from the same class, over a long period of time.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eUnderdosing which may result from underestimation of the animals' body weight, incorrect administration of the product or lack of calibration of the dosing device (if applicable).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eClinical cases suspected of anthelmintic resistance should be further investigated using appropriate laboratory tests (such as the Faecal Egg Count Reduction Test). When test results show resistance to a particular anthelmintic, an anthelmintic belonging to a different pharmacological class and having a different mode of action should be used.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eTo date, resistance to eprinomectin (a macrocyclic lactone) has not been reported in the EU. However, resistance to other macrocyclic lactones has been reported in the EU in parasitic species of cattle. The use of this product should be based on local epidemiological information (region, farms) on the susceptibility of nematodes and recommendations on how to limit the development of resistance to anthelmintics.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eSPECIAL PRECAUTIONS\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSpecial precautions for use in animals\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe usual rules of asepsis for the administration of injectable preparations must be observed. Do not use in other species: avermectins can cause mortality in dogs, especially in Collies, Bobtails, related breeds and crossbreeds, and also in tortoises. To avoid adverse reactions caused by the death of Hypoderma spp. larvae in the oesophagus and spinal canal of cattle, it is recommended to administer the product immediately after the insect has finished its activity and before the larvae reach these areas. Seek the advice of a veterinarian to establish the correct period for administering the treatment.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThis veterinary medicinal product causes severe eye irritation. Avoid contact with eyes! If splashed into eyes, rinse immediately with water.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThis product may cause neurotoxicity. Care should be taken when handling the product to avoid self-injection. In case of accidental self-injection, seek medical advice immediately and show the package leaflet and label to the physician. Avoid contact with skin. In case of accidental splashes, wash immediately with water. Avoid oral exposure. Do not eat, drink or smoke while handling this veterinary medicinal product. Wash hands after use. The excipient glycerol may cause foetal harm. In addition, the active substance eprinomectin may pass into breast milk. Pregnant or lactating women and women of childbearing potential should avoid contact with this product.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDo not use this product in case of known hypersensitivity to the active substance or to any of the excipients.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eEprinomectin is very toxic to aquatic organisms, persists in soil and may accumulate in sediments. The risk to aquatic ecosystems and dung fauna can be reduced by avoiding too frequent and repeated use of eprinomectin (and products of the same anthelmintic class) in cattle.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe risk to aquatic ecosystems will be reduced by keeping treated cattle away from watercourses for two to five weeks after treatment.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eADVERSE REACTIONS\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eModerate to severe swelling at the injection site is very common. The swelling usually resolves within 7 days, but the areas may remain indurated for more than 21 days. The swelling may be accompanied by mild to moderate pain. This reaction resolves without treatment and does not affect the safety or efficacy of the product.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eUSE DURING PREGNANCY, LACTATION OR LAYING PERIOD\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe product can be used during pregnancy or lactation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eINTERACTIONS WITH OTHER MEDICINAL PRODUCTS OR OTHER FORMS OF INTERACTION\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSince eprinomectin binds tightly to plasma proteins, this should be taken into account when combining with other molecules with the same characteristics.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eDOSAGE AND METHOD OF ADMINISTRATION\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSubcutaneous administration.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eA single administration of 0.2 mg eprinomectin per kg body weight; corresponding to 1 ml of veterinary medicinal product per 100 kg body weight.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e50 ml or 100 ml vials: Do not exceed 30 punctures per vial. If more than 30 punctures are required, it is recommended to use a separate needle to withdraw the product.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e250 ml or 500 ml bottles\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDo not exceed 20 punctures per vial. If more than 20 punctures are required, it is recommended to use a separate needle to withdraw the product.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn order to administer a correct dose, body weight should be determined as accurately as possible. The accuracy of the dosing equipment should also be checked.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eOverdose (symptoms, emergency procedures, antidotes), as appropriate\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eAfter subcutaneous administration of a dose up to 5 times the recommended dose, no adverse reactions were observed except for a transient reaction (inflammation followed by induration) at the site of administration.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eWaiting time\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eCattle - Offal and offal: 63 days - Milk: zero hours\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSheep - Meat and offal: 42 days - Milk: zero hours\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eGoats - Meat and offal: 42 days - Milk: zero hours\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eincompatibility\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIn the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eVALIDITY PERIOD\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eShelf life of the veterinary medicinal product as packaged for sale: 3 years.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eShelf life after first opening the immediate packaging: 6 months.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eSPECIAL STORAGE PRECAUTIONS\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThis veterinary medicinal product does not require any special storage conditions.\u003c\/span\u003e\u003c\/p\u003e\n\u003c!----\u003e","brand":"Pet Shop Luna SRL","offers":[{"title":"Default Title","offer_id":48805235130715,"sku":"","price":124.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0476\/3261\/3543\/files\/3348325_product_e0f6ce45-1b1f-49aa-b410-77c4a8384c0a.jpg?v=1723110878","url":"https:\/\/www.petshopluna.com\/en-gb\/products\/eprecis-inj-100ml-eprinomectin-for-cows-per-bovini","provider":"Pet Shop Maya","version":"1.0","type":"link"}