{"product_id":"nexgard-spectra-chewable-3-tablets-for-extra-large-dogs-prevention-of-heartworm-disease","title":"NexGard Spectra Chewable 3 Tablets for Dogs prevention of heartworm disease \/  Antiparassitario \/ vermifugo per cani 3 compresse EUROPEAN VERSION","description":"\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eCLINICAL PARTICULARS\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eTarget species: \u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Dogs\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003cspan\u003eIndications for use, specifying the target species\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eFor the treatment of flea and tick infestations in dogs when the prevention of cardiac dirofilariasis and\/or the treatment against infestations with gastrointestinal nematodes is also indicated.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eTreatment of flea infestations ( \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eCtenocephalides felis\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e and \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eC. canis\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e ) in dogs for 5 weeks. Treatment of tick infestations ( \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eDermacentor reticulatus, Ixodes ricinus, Rhipicephalus sanguineus\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e ) in dogs for 4 weeks\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eFleas and ticks must be attached to the host and begin the feeding process to be exposed to the active substance.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eTreatment of infestations with adult gastrointestinal nematodes of the following species: roundworms ( \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eToxocara canis\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e and \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eToxocara leonina\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e ), hookworms ( \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eAncyclostoma caninum\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e and \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eAncyclostoma braziliense\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e ) and whipworms ( \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eTrichuris vulpis\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e ).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePrevention of cardiac heartworm disease ( \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eDirofilaria immitis\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e larval stage) if administered monthly.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003cspan\u003eContraindications: \u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Do not use in case of hypersensitivity to the active substances or to any of the excipients.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cstrong\u003e\u003cspan\u003eSpecial precautions for each target species\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cspan\u003eParasites must begin feeding on the host to be exposed to afoxolaner; therefore, the risk of transmitting infectious diseases cannot be excluded.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003e Parasite resistance to a certain class of antiparasitic drugs can develop as a result of frequent use of a compound of that class. Therefore, the use of this product must be based on a case-by-case assessment and local epidemiological information on the current susceptibility of the target species to limit the possibility of future selection of resistance.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003e Maintaining the effectiveness of macrocyclic lactones is essential in the control \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eof Dirofilaria immitis\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e . In order to minimize the risk of resistance selection, it is recommended to test dogs for both circulating antigens and blood microfilariae at the beginning of each preventive treatment period.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eOnly negative animals should be treated\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003cspan\u003eSpecial precautions for use\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eSpecial precautions for use in animals\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eIn the absence of available data, the treatment of puppies less than 8 weeks old and\/or dogs weighing less than 2 kg should only be carried out based on the assessment of the risk\/benefit ratio by the veterinarian.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eDogs living in areas endemic for cardiovascular heartworm disease should be tested for adult heartworm infestation prior to administration of NEXGARD SPECTRA. Infested dogs must be treated with an adulticide at the veterinarian's choice to eliminate adult heartworms. NEXGARD SPECTRA is not indicated for the elimination of microfilariae.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eThe recommended dosage must be strictly followed in the case of dogs of the Collie breed or other breeds related to it.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003e This product may cause gastrointestinal disturbances if ingested.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eKeep the tablets in blisters and the blister in the box until use.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eIn case of accidental ingestion, especially by children, seek medical advice immediately and show the product label.\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eWash hands after use.\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003cspan\u003eAdverse reactions (frequency and severity)\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eIn clinical trials, there were no serious adverse reactions attributed to the combination of afoxolaner with milbemycin oxime. Uncommon reactions such as: vomiting, diarrhea, lethargy, anorexia and pruritus have been observed. These reactions generally resolved on their own and were of short duration.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eThe frequency of adverse reactions is defined using the following convention:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003e- Very common (more than 1 in 10 animals showing adverse reactions during treatment)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003e- Frequent (more than 1 but less than 10 animals out of 100 animals)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003e- Uncommon (more than 1 but less than 10 animals in 1000 animals)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003e- Rare (more than 1 but less than 10 animals in 10,000 animals)\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003e- Very rare (less than 1 animal in 10,000 animals, including isolated reports).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003cspan\u003eUse during pregnancy, lactation or during the laying period\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eLaboratory studies in rats and rabbits have not shown teratogenic effects or any adverse effect on male or female reproductive capacity. The safety of the veterinary medicinal product has not been established during pregnancy and lactation or for breeding dogs. To be used in accordance with the benefit-risk assessment of the veterinarian.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003cspan\u003eInteractions with other medicinal products or other forms of interaction\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eMilbemycin oxime is a p-glycoprotein (P-gp) substrate, so it may interact with other P-gp substrates (eg, digoxin, doxorubicin) or other macrocyclic lactones. Therefore, concomitant treatment with other P-gp substrates may lead to increased toxicity.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003cspan\u003eQuantities to be administered and route of administration\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eFor oral administration.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eDosage:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eThe product should be administered at a dose of 2.50-5.36 mg\/kg of afoxolaner and 0.50-1.07 mg\/kg of milbemycin oxime body weight according to the following table:\u003c\/span\u003e\u003c\/p\u003e\n\u003ctable border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd rowspan=\"2\" valign=\"top\" width=\"97\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eDog weight (kg)\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd colspan=\"5\" valign=\"top\" width=\"522\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eThe concentration and number of chewable tablets to be administered\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003eNEXGARD SPECTRA\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003e9 mg\/ 2 mg\u003c\/span\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003eNEXGARD SPECTRA\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003e19 mg\/ 4 mg\u003c\/span\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003eNEXGARD SPECTRA\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003e38 mg\/ 8 mg\u003c\/span\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003eNEXGARD SPECTRA\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003e75 mg\/ 15 mg\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003eNEXGARD SPECTRA\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003e150 mg\/ 30 mg\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003e2-3.5\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003e1\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003e\u0026gt;3.5-7.5\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003e1\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003e\u0026gt;7.5-15\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003e1\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003e\u0026gt;15-30\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003e1\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd valign=\"top\" width=\"97\"\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003e\u0026gt;30-60\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"96\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"102\"\u003e\n\u003cp align=\"center\"\u003e \u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd valign=\"top\" width=\"120\"\u003e\n\u003cp align=\"center\"\u003e\u003cspan\u003e1\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003e For dogs over 60 kg of body weight, the necessary combination of chewable tablets will be used\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eMethod of administration:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eThe tablets are chewable and pleasant to the taste for most dogs. If the dog does not accept the tablets directly, they can be administered together with food.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eTreatment scheme:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eThe treatment plan must be based on the veterinary diagnosis and the local epidemiological situation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eNEXGARD SPECTRA can be used as a seasonal preventive treatment against fleas and ticks (replacing the treatment with a monovalent product with action only against fleas and ticks) in dogs co-infested with gastrointestinal nematodes. A single treatment is effective against gastrointestinal nematodes. After treating nematode infestations, treatment against flea and tick infestations can be continued by applying the monovalent product.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cem\u003e\u003cspan\u003eDisease: Cardiac heartworm disease:\u003c\/span\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003e\u003c\/span\u003e\u003cem\u003e\u003cspan\u003eNEXGARD SPECTRA kills Dirofilaria immitis\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e larvae within one month of transmission by mosquitoes, therefore the product should be administered at regular monthly intervals throughout the vector-prone periods, beginning one month after the first exposure to mosquitoes. Treatment should be continued until the month following the last exposure to mosquitoes. In order to establish a treatment routine, it is recommended to administer the treatment on the same day of the month.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eIf replacing another cardiac heartworm prevention product, the first treatment with NEXGARD SPECTRA should begin on the day the previous medication was due.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eDogs that live in or have traveled to an area with cardiac heartworm disease can be infested with adult heartworms. No therapeutic effect has been established against adult \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eDirofilaria immitis\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e . It is therefore recommended that all dogs 8 months of age or older living in heartworm endemic areas be tested for adult heartworm infestation before being treated with a heartworm prevention product.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cstrong\u003e\u003cspan\u003eOverdose (symptoms, emergency procedures, antidotes), as appropriate\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eNo adverse reactions were observed in healthy puppies over 8 weeks of age after 6 treatments with 5 times the maximum dose.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003cstrong\u003e\u003cspan\u003eWaiting time: \u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Not applicable.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003cspan\u003ePHARMACOLOGICAL PROPERTIES\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003ePharmacotherapeutic group: antiparasitic products, endectocides, milbemycin combinations.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eATC veterinary code: QP54AB51\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003cspan\u003ePharmacodynamic properties\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cspan\u003eAfoxolaner\u003c\/span\u003e\u003cspan\u003e :\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eAfoxolaner is an insecticide and acaricide belonging to the isoxazoline family.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003e Afoxolaner acts by interacting with chloride ion channels, mainly those with a binding site for the neurotransmitter gamma-aminobutyric acid (GABA), thus blocking the pre- and post-synaptic transfers of chloride ions across the cell membrane. This results in an uncontrolled activity of the central nervous system and the death of insects and mites. The selective toxicity of afoxolaner between insects\/mites and mammals is a consequence of the characteristic sensitivity of insect\/mite versus mammalian GABA receptors.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003e Afoxolaner is active against adult fleas as well as tick species such as \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eRhipicephalus sanguineus, Dermacentor reticulatus\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e and \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eD. variabilis, Ixodes ricinus\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e and \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eI. scapularis, Amblyomma americanum\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e and \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eHaemaphysalis longicornis.\u003c\/span\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eThe product kills fleas before laying eggs and thus prevents contamination of the house. It can be used as part of the treatment strategy for the control of allergic flea dermatitis (FAD). \u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eMilbemycin oxime:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eMilbemycin oxime is an antiparasitic endectocide that belongs to the group of macrocyclic lactones. Milbemycin oxime is the mixture of milbemycin A \u003c\/span\u003e\u003csub\u003e\u003cspan\u003e4\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e and milbemycin A \u003c\/span\u003e\u003csub\u003e\u003cspan\u003e3\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e (in a ratio of 20:80 for A \u003c\/span\u003e\u003csub\u003e\u003cspan\u003e3\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e :A \u003c\/span\u003e\u003csub\u003e\u003cspan\u003e4\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e ). It is isolated from the fermentation of \u003c\/span\u003e\u003cem\u003e\u003cspan\u003eStreptomyces milbemycinicus\u003c\/span\u003e\u003c\/em\u003e\u003cspan\u003e .\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eMilbemycin oxime acts by disrupting glutamate-activated neurotransmission in invertebrates. Milbemycin oxime increases membrane permeability of nematodes and insects to chloride ions through glutamate-gated chloride ion channels (linked to GABA and glycine receptors in vertebrates).\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eThis leads to hyperpolarization of the neuromuscular membrane and paralysis and death of the parasites.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003cspan\u003ePharmacokinetic peculiarities\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cspan\u003eAfoxolaner is very rapidly absorbed systemically. The absolute bioavailability obtained was 88%. The mean value of the maximum plasma concentration (C \u003c\/span\u003e\u003csub\u003e\u003cspan\u003emax\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e ) was 1822 ± 165 ng\/ml, 2-4 hours (T \u003c\/span\u003e\u003csub\u003e\u003cspan\u003emax\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e ) after a dose of 2.5 mg\/kg afoxolaner.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe distribution volume of Afoxolaner at the tissue level is 2.6 ± 0.6 l\/kg and the clearance value is 5.0 ± 1.2 ml\/h\/kg. The half-life is approximately 2 weeks in dogs.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003ePlasma concentrations of Milbemycin oxime increase rapidly in the first 1-2 hours (T \u003c\/span\u003e\u003csub\u003e\u003cspan\u003emax\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e ), indicating rapid absorption from the tablet. The absolute bioavailability obtained was 81% for factor A \u003c\/span\u003e\u003csub\u003e\u003cspan\u003e3\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e and respectively 65% ​​for A \u003c\/span\u003e\u003csub\u003e\u003cspan\u003e4.\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e The average value of the maximum plasma concentration (C \u003c\/span\u003e\u003csub\u003e\u003cspan\u003emax\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e ), following oral administration, was 1.6 ± 0.4 days and 42 ± 11 ng\/ml for A \u003c\/span\u003e\u003csub\u003e\u003cspan\u003e3\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e , 3.3 ± 1.4 days and 246 ± 71 ng\/ml for A \u003c\/span\u003e\u003csub\u003e\u003cspan\u003e4\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e .\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cspan\u003eThe distribution volume of Milbemycin oxime at the tissue level is 2.7 ± 0.4 and 2.6 ± 0.6 l\/kg for form A \u003c\/span\u003e\u003csub\u003e\u003cspan\u003e3 and A \u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e\u003c\/span\u003e\u003csub\u003e\u003cspan\u003e4\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e respectively . Both forms have a low clearance value of 75 ± 22 ml\/h\/kg for A \u003c\/span\u003e\u003csub\u003e\u003cspan\u003e3\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e and 41 ± 12 ml\/h\/kg for A \u003c\/span\u003e\u003csub\u003e\u003cspan\u003e4\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e .\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e \u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003cspan\u003ePHARMACEUTICAL PARTICULARS\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003c\/strong\u003e\u003cstrong\u003e\u003cspan\u003eList of excipients\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cspan\u003eCorn starch\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eSoy protein\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eStewed beef flavoring\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003ePovidone (E1201)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMacrogol 400\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMacrogol 4000\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMacrogol 15 hydroxystearate\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eGlycerol (E422)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eMedium chain triglycerides\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eCitric acid monohydrate (E330)\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan\u003eButyl hydroxytoluene (E321)\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003cspan\u003eIncompatibilities: \u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Not applicable.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e\u003cspan\u003eShelf life: \u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Shelf life of the veterinary medicinal product as packaged for sale: 2 years\u003c\/span\u003e\u003c\/p\u003e\n\u003cp align=\"left\"\u003e\u003cstrong\u003e \u003c\/strong\u003e\u003cstrong\u003e\u003cspan\u003eSpecial precautions for storage: \u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Keep the blister in the secondary packaging in order to protect from light.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e","brand":"MERIAL","offers":[{"title":"XS 2-3.5KG","offer_id":37944211046567,"sku":"","price":52.9,"currency_code":"EUR","in_stock":true},{"title":"S 3.5-7.5KG","offer_id":37944211079335,"sku":"","price":54.9,"currency_code":"EUR","in_stock":true},{"title":"M 7.5-15KG","offer_id":37944211112103,"sku":"","price":61.9,"currency_code":"EUR","in_stock":true},{"title":"L 15-30KG","offer_id":37944211144871,"sku":"","price":65.9,"currency_code":"EUR","in_stock":true},{"title":"XL 30-60KG","offer_id":37944211177639,"sku":"","price":72.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0476\/3261\/3543\/products\/nexgard_30_60_kg__55201__50505.jpg?v=1617467087","url":"https:\/\/www.petshopluna.com\/en-de\/products\/nexgard-spectra-chewable-3-tablets-for-extra-large-dogs-prevention-of-heartworm-disease","provider":"Pet Shop Maya","version":"1.0","type":"link"}