{"product_id":"tyloplus-30-100-ml-injectable-tilmicosin-300-mg-cattle-bovini","title":"TYLOPLUS 30% 100 ML INJECTABLE \/\/ Tilmicosin 300 MG \/\/ cattle\/ BOVINI","description":"\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eNAME OF THE VETERINARY MEDICINAL PRODUCT:\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003eTYLOPLUS INJ,\u003c\/strong\u003e\u003cstrong\u003e \u003c\/strong\u003e 300 mg\/ml, injectable solution for cattle.\u003cbr\u003e tilmicosin.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eSTATEMENT OF ACTIVE SUBSTANCE AND OTHER INGREDIENTS\u003c\/strong\u003e\u003cbr\u003e1 ml of product contains:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eActive substance:\u003c\/strong\u003e\u003cbr\u003eTilmicosin……………………………………………………..300 mg.\u003cbr\u003e\u003cstrong\u003eExcipients: \u003c\/strong\u003e orthophosphoric acid, propylene glycol (E 1520), water for injections.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eINDICATIONS:\u003c\/strong\u003e\u003cbr\u003eThe product is indicated for cattle in the treatment of pulmonary infections caused by  \u003cem\u003eMannheimia haemolitica and Pasteurella mutocida\u003c\/em\u003e , sensitive to tilmicosin.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eCONTRAINDICATIONS:\u003c\/strong\u003e\u003cbr\u003eDo not use in case of hypersensitivity to the active substance or to any of the excipients.\u003cbr\u003eIt is not administered intravenously.\u003cbr\u003eIt is not used in cows that produce milk for human consumption.\u003cbr\u003eDo not administer to pigs, sheep, goats.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eTARGET SPECIES: \u003c\/strong\u003e\u003cbr\u003eCattle.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eDOSAGE FOR EACH SPECIES, ROUTE(S) OF ADMINISTRATION AND METHOD OF ADMINISTRATION:\u003c\/strong\u003e\u003cbr\u003eThe recommended dose is 10 mg tilmicosin per kg of body weight, in a single dose equivalent to 1 ml of product per 30 kg of body weight.\u003cbr\u003eIt is administered subcutaneously.\u003cbr\u003eTo ensure a correct dose, the weight of the animals will be determined as precisely as possible, in order to avoid overdose.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eRECOMMENDATIONS REGARDING THE CORRECT ADMINISTRATION\u003c\/strong\u003e\u003cbr\u003eExtract the required dose from the bottle and withdraw the needle from the syringe. If several animals need to be treated, the needle is left in the bottle for taking subsequent doses. The animals are immobilized and the injection with a separate needle for each individual animal is done subcutaneously in a fold of the skin behind the shoulder. Do not inject more than 20 ml in a single point.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eWAITING TIME:\u003c\/strong\u003e\u003cbr\u003eCattle (meat and organs): 28 days.\u003cbr\u003eIt is not authorized for use in animals that produce milk for human consumption.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003ePRECAUTIONS\u003c\/strong\u003e\u003cbr\u003ePrecautions for the person administering the product:\u003cbr\u003eAvoid contact with the eyes;\u003cbr\u003eIt can cause sensitivity in contact with the skin; Wash hands after use.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eNOTE FOR DOCTORS:\u003c\/strong\u003e\u003cbr\u003eINJECTION OF THIS PRODUCT IN HUMANS IS ASSOCIATED WITH DEATH\u003cbr\u003eThe cardiovascular system is the target for toxicity and this toxicity may be due to the blocking of calcium channels.\u003cbr\u003eADRENALINE OR BETA-ADRENERGIC ANTAGONISTS SUCH AS PROPANOLOL ARE NOT ADMINISTERED.\u003cbr\u003eIn pigs, the mortality rate induced by tilmicosin increases when adrenaline is administered.\u003cbr\u003eIn dogs, treatment with intravenous calcium chloride showed a positive effect on the inotropic status of the left ventricle and a certain improvement in vascular tension and tachycardia.\u003cbr\u003ePreclinical reports and a clinical report show that in humans, calcium chloride infusion can reverse the changes in blood pressure and heart rate induced by tilmicosin.\u003cbr\u003eThe administration of dobutamine must be taken into account, considering the positive inotropic effects, although this has no influence on tachycardia given the fact that tilmicosin remains present in the tissues for several days, the cardiovascular system must be closely monitored, administering and a supportive treatment.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eUse during pregnancy or during lactation:\u003c\/strong\u003e\u003cbr\u003eStudies performed on laboratory animals have not revealed an embryotoxic or teratogenic potential. The safety of the product has not been demonstrated during a period of pregnancy and lactation.\u003cbr\u003eThe use of the product during pregnancy and lactation is done after evaluating the benefit\/risk balance.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eOVERDOSAGE\u003c\/strong\u003e\u003cbr\u003eSubcutaneous administration of doses of 10, 30, 50 mg\/kg body weight, in three rounds at an interval of 72 hours, did not cause mortality. Subcutaneous injection of a dose of 150 mg\/kg body weight at an interval of 72 hours produced death. Death also occurred after the administration of a dose of 5 mg\/kg in intravenous injection.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003ePRESENTATION\u003c\/strong\u003e\u003cbr\u003ePolypropylene bottles 100 ml.\u003cbr\u003eNot all pack sizes may be marketed.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eDENOMINAZIONE DEL MEDICINALE VETERINARIO:\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003eTYLOPLUS INJ,\u003c\/strong\u003e\u003cstrong\u003e \u003c\/strong\u003e 300 mg\/ml, soluzione iniettabile per bovini.\u003cbr\u003e tilmicosina.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eINDICAZIONE DEL PRINCIPIO ATTIVO E DEGLI ALTRI INGREDIENTI\u003c\/strong\u003e\u003cbr\u003e1 ml di prodotto contiene:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003ePrincipio attivo:\u003c\/strong\u003e\u003cbr\u003eTilmicosina……………………………..300 mg.\u003cbr\u003e\u003cstrong\u003eEccipienti: \u003c\/strong\u003e acido ortofosforico, glicole propilenico (E 1520), acqua per preparazioni iniettabili.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eINDICAZIONI:\u003c\/strong\u003e\u003cbr\u003eIl prodotto è indicato nei bovini nel trattamento delle infezioni polmonari causate da  \u003cem\u003eMannheimia haemolitica e Pasteurella mutocida\u003c\/em\u003e , sensibili alla tilmicosina.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eCONTROINDICAZIONI:\u003c\/strong\u003e\u003cbr\u003eNon utilizzare in caso di ipersensibilità al principio attivo o ad uno qualsiasi degli eccipienti.\u003cbr\u003eNon viene somministrato per via endovenosa.\u003cbr\u003eNon è utilizzato nelle mucche che producono latte destinato al consumo umano.\u003cbr\u003eNon somministrare a suini, pecore, capre.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eSPECIE DI DESTINAZIONE: \u003c\/strong\u003e\u003cbr\u003eBovini.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003ePOSOLOGIA PER CIASCUNA SPECIE, VIA(E) DI SOMMINISTRAZIONE E MODALITÀ DI SOMMINISTRAZIONE:\u003c\/strong\u003e\u003cbr\u003eLa dose raccomandata è di 10 mg di tilmicosina per kg di peso corporeo, in una singola dose equivalente a 1 ml di prodotto per 30 kg di peso corporeo.\u003cbr\u003eViene somministrato per via sottocutanea.\u003cbr\u003ePer garantire una dose corretta, il peso degli animali sarà determinato nel modo più preciso possibile, in modo da evitare un sovradosaggio.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eRACCOMANDAZIONI PER UNA CORRETTA SOMMINISTRAZIONE\u003c\/strong\u003e\u003cbr\u003eEstrarre la dose necessaria dal flacone e ritirare l'ago dalla siringa. Se è necessario trattare più animali, l'ago viene lasciato nel flacone per l'assunzione delle dosi successive. Gli animali vengono immobilizzati e l'iniezione con un ago separato per ogni singolo animale viene effettuata per via sottocutanea in una piega della pelle dietro la spalla. Non iniettare più di 20 ml in un unico punto.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eTEMPO DI ATTESA:\u003c\/strong\u003e\u003cbr\u003eBovini (carne e organi): 28 giorni.\u003cbr\u003eNon è autorizzato l'uso negli animali che producono latte destinato al consumo umano.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003ePRECAUZIONI\u003c\/strong\u003e\u003cbr\u003ePrecauzioni per chi somministra il prodotto:\u003cbr\u003eEvitare il contatto con gli occhi;\u003cbr\u003ePuò provocare sensibilità a contatto con la pelle; Lavarsi le mani dopo l'uso.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eNOTA PER I MEDICI:\u003c\/strong\u003e\u003cbr\u003eL'INIEZIONE DI QUESTO PRODOTTO NELL'UOMO È ASSOCIATA ALLA MORTE\u003cbr\u003eIl sistema cardiovascolare è il bersaglio della tossicità e questa tossicità può essere dovuta al blocco dei canali del calcio.\u003cbr\u003eNON VENGONO SOMMINISTRATI ANTAGONISTI ADRENALINICI O BETA-ADRENERGICI COME IL PROPANOLOLO.\u003cbr\u003eNei suini, il tasso di mortalità indotto dalla tilmicosina aumenta quando viene somministrata adrenalina.\u003cbr\u003eNei cani, il trattamento con cloruro di calcio per via endovenosa ha mostrato un effetto positivo sullo stato inotropo del ventricolo sinistro e un certo miglioramento della tensione vascolare e della tachicardia.\u003cbr\u003eRelazioni precliniche e una relazione clinica mostrano che nell’uomo l’infusione di cloruro di calcio può invertire le variazioni della pressione sanguigna e della frequenza cardiaca indotte dalla tilmicosina.\u003cbr\u003eDa tenere in considerazione la somministrazione di dobutamina, considerati gli effetti inotropi positivi, anche se questa non ha alcuna influenza sulla tachicardia dato che la tilmicosina rimane presente nei tessuti per diversi giorni, il sistema cardiovascolare deve essere attentamente monitorato, somministrando un trattamento di supporto. .\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eUso durante la gravidanza o l'allattamento:\u003c\/strong\u003e\u003cbr\u003estudi condotti su animali da laboratorio non hanno rivelato un potenziale embriotossico o teratogeno. La sicurezza del prodotto non è stata dimostrata durante il periodo di gravidanza e allattamento.\u003cbr\u003eL'uso del prodotto durante la gravidanza e l'allattamento viene effettuato dopo aver valutato il rapporto beneficio\/rischio.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003eSOVRADOSAGGIO\u003c\/strong\u003e\u003cbr\u003eLa somministrazione sottocutanea di dosi di 10, 30, 50 mg\/kg di peso corporeo, in tre cicli ad un intervallo di 72 ore, non ha causato mortalità. L'iniezione sottocutanea di una dose di 150 mg\/kg di peso corporeo ad un intervallo di 72 ore ha provocato la morte. La morte si è verificata anche dopo la somministrazione di una dose di 5 mg\/kg tramite iniezione endovenosa.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003ePRESENTAZIONE\u003c\/strong\u003e\u003cbr\u003eBottiglie in polipropilene 100 ml.\u003cbr\u003eÈ possibile che non tutte le confezioni siano commercializzate.\u003c\/span\u003e\u003c\/p\u003e","brand":"Crida Pharm","offers":[{"title":"Default Title","offer_id":49615948513627,"sku":"","price":46.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0476\/3261\/3543\/files\/864938_product.jpg?v=1733219776","url":"https:\/\/www.petshopluna.com\/en-at\/products\/tyloplus-30-100-ml-injectable-tilmicosin-300-mg-cattle-bovini","provider":"Pet Shop Maya","version":"1.0","type":"link"}