{"product_id":"spirovet-100ml-inj-spiramicina-cattle-pigs-bovini-e-suini","title":"SPIROVET 100ML INJ. \/\/ Spiramycin \/\/ cattle, pigs \/ bovini e suini","description":"\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eNAME OF THE VETERINARY MEDICINAL PRODUCT\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003cspan\u003eSPIROVET 600,000 IU\/ml,\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003einjectable solution for cattle.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eSTATEMENT OF ACTIVE SUBSTANCES AND OTHER INGREDIENTS\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003e1 ml of solution contains:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eSpiramycin 600,000 IU;\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eBenzyl alcohol 41.6 mg;\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eClear yellow solution.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eINDICATIONS\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eTreatment of acute clinical mastitis in lactating cows caused by Staphylococcus aureus\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003estrains sensitive to spiramycin. Treatment of respiratory infections caused by Pasteurella multocida and Mannheimia haemolytica.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eCONTRAINDICATIONS\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eDo not use in case of hypersensitivity to spiramycin.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eADVERSE REACTIONS\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eAt the injection site, the product may sometimes induce some macroscopic lesions, which may persist\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003efor more than 42 days.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eIn cattle, hypersalivation may occur 3 hours after administration.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eIf you notice any serious reactions or other effects not mentioned in this leaflet, please inform your veterinarian.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eTARGET SPECIES\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eCattle, pigs.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eDOSAGE FOR EACH SPECIES, ROUTE(S) OF ADMINISTRATION AND METHOD OF ADMINISTRATION\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eAdministered intramuscularly:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eBody weight should be determined as accurately as possible to avoid underdosing.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eMastitis: 30,000 IU spiramycin\/kg body weight (e.g. 5 ml product for 100 kg\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003ebody weight), two doses at 24-hour intervals.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eRespiratory infections: 100,000 IU spiramycin\/kg body weight (e.g. 5 ml product for 30 kg body weight), two doses at 48-hour intervals.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eRECOMMENDATIONS ON CORRECT ADMINISTRATION\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eDo not administer more than 15 ml. at one site.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eThis means that the dose should be divided into two injections, then the injections should be made on opposite sides of the neck. If more than 2 injections are required, a distance of at least 15 cm. should be maintained between injections on the same side of the neck.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eFor the second dose (after 24 or 48 hours), the same protocol should be followed, ensuring that a distance of at least 15 cm is maintained between all sites of product administration. This procedure is necessary so that the injection sites remain separate. Failure to follow these instructions may result in exceeding the maximum residue limit of 200 μg\/kg for muscle.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eWITHDRAWAL TIME\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eMastitis:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eMeat and offal: 75 days.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eMilk: 13.5 days.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eRespiratory infections:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eMeat and offal: 75 days.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eMilk: In the case of treatment with appropriate doses for respiratory infections, the product is not authorised for administration to animals producing milk for human consumption.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003ePRECAUTIONS FOR USE IN ANIMALS\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eDo not administer more than 15 ml at a single site to cattle.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eThe use of the product should be based on antimicrobial resistance testing of bacteria isolated from the animals. If this is not possible, therapy should be based on local (regional, farm level) epidemiological information on the susceptibility of the target bacteria. Use of the product deviating from the instructions in the package leaflet may increase the prevalence of bacterial resistance to spiramycin. Official national and regional antimicrobial policies should be taken into account when using the product.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eMastitis caused by S.aureus should only be treated after the appearance of clinical signs. Only acute cases of mastitis caused by S.aureus with clinical signs and kept under observation for at least 24 hours should be treated.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eUSE DURING PREGNANCY, LACTATION OR LAYING\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eNo teratogenic effects have been reported in mice. Oral maternotoxic doses caused embryotoxicity in rabbits. The safety of the product has not been established in cows during gestation and lactation. However, use of the product during gestation and lactation should not raise toxicological concerns. Laboratory studies in dogs and rats have shown effects on spermatogenesis at high doses of 2,050,000 IU\/kg body weight per day for 56 days. The safety of the product has not been established in breeding males. In these animals, the use of the product should be based on a benefit\/risk assessment by the veterinarian.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eOVERDOSAGE\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eDue to the fact that the toxicity of spiramycin is low, an overdose does not produce toxic effects.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eINCOMPATIBILITY\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eIn the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003ePHARMACODYNAMIC PROPERTIES\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eSpiramycin acts on bacterial protein synthesis by binding to the 50S ribosomal subunit, inhibiting the translocation phase. Spiramycin is capable of reaching high tissue concentrations, managing to penetrate intracellularly and bind to the 50S ribosomal subunit.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe following minimum inhibitory concentrations (MICs) were determined on European strains isolated from diseased animals between 2007 and 2012:\u003c\/span\u003e\u003c\/p\u003e\n\u003ctable cellspacing=\"0\" cellpadding=\"0\" border=\"1\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd rowspan=\"2\"\u003e\n\u003cp\u003e\u003cspan\u003eBacterial species\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd rowspan=\"2\"\u003e\n\u003cp\u003e\u003cspan\u003eOrigin\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd rowspan=\"2\"\u003e\n\u003cp\u003e\u003cspan\u003eNo. of stems\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd colspan=\"3\"\u003e\n\u003cp\u003e\u003cspan\u003eSpiramycin MIC (μg\/mL)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003eRange\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003eMIC \u003c\/span\u003e\u003csub\u003e\u003cspan\u003e50\u003c\/span\u003e\u003c\/sub\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003eCMI \u003c\/span\u003e\u003csub\u003e\u003cspan\u003e90\u003c\/span\u003e\u003c\/sub\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cem\u003e\u003cspan\u003ePasteurella multocida\u003c\/span\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003eCattle\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e129\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e1- ≥512\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e16\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e32\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cem\u003e\u003cspan\u003eMannheimia haemolytica\u003c\/span\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003eCattle\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e149\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e4 - 512\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e64\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e128\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cem\u003e\u003cspan\u003eStaphylococcus aureus\u003c\/span\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003eCattle\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e211\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e1 -≥64\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e4\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e8\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003ePHARMACOKINETICS\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eFollowing intramuscular administration, spiramycin is rapidly absorbed and reaches peak plasma concentrations within three hours. Spiramycin is metabolized in the liver, its primary metabolite, neospiramycin, possessing antibacterial activity. It is eliminated mainly by biliary excretion.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eDENOMINAZIONE DEL MEDICINALE VETERINARIO\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cstrong\u003e\u003cspan\u003eSPIROVET 600.000 UI\/ml,\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003esoluzione iniettabile per bovini.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eINDICAZIONE DEI PRINCIPI ATTIVI E DEGLI ALTRI INGREDIENTI\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003e1 ml. di soluzione contiene:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eSpiramicina 600.000 UI;\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eAlcool benzilico 41,6 mg;\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eSoluzione gialla limpida.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eINDICAZIONI\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eTrattamento della mastite clinica acuta nelle vacche in lattazione causata da\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eceppi di Staphylococcus aureus sensibili alla spiramicina. Trattamento delle infezioni respiratorie causate da Pasteurella multocida e Mannheimia haemolytica.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eCONTROINDICAZIONI\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eNon usare in caso di ipersensibilità alla spiramicina.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eREAZIONI AVVERSE\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eNel sito di iniezione, il prodotto può talvolta indurre alcune lesioni macroscopiche, che possono persistere\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eper più di 42 giorni.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eNei bovini, l'ipersalivazione può verificarsi 3 ore dopo la somministrazione.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eSe si notano reazioni gravi o altri effetti non menzionati in questo foglio illustrativo, informare il veterinario.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eSPECIE DESTINATARI\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eBovini, suini.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eDOSAGGIO PER CIASCUNA SPECIE, VIA(E) DI SOMMINISTRAZIONE E MODALITÀ DI SOMMINISTRAZIONE\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eSomministrato per via intramuscolare:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eil peso corporeo deve essere determinato nel modo più accurato possibile per evitare un sottodosaggio.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eMastite: 30.000 UI di spiramicina\/kg di peso corporeo (ad esempio 5 ml di prodotto ogni 100 kg\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003edi peso corporeo), due dosi a distanza di 24 ore.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eInfezioni respiratorie: 100.000 UI di spiramicina\/kg di peso corporeo (ad esempio 5 ml di prodotto per 30 kg di peso corporeo), due dosi a intervalli di 48 ore.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eRACCOMANDAZIONI PER UNA CORRETTA SOMMINISTRAZIONE\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eNon somministrare più di 15 ml. in un unico posto.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eCiò significa che la dose deve essere suddivisa in due iniezioni, che devono essere somministrate su lati opposti del collo. Se sono necessarie più di 2 iniezioni, è necessario mantenere una distanza di almeno 15 cm. tra le iniezioni sullo stesso lato del collo.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003ePer la seconda dose (dopo 24 o 48 ore), è necessario seguire lo stesso protocollo, assicurandosi di mantenere una distanza di almeno 15 cm tra tutti i siti di somministrazione del prodotto. Questa procedura è necessaria affinché i siti di iniezione rimangano separati. La mancata osservanza di queste istruzioni può comportare il superamento del limite massimo di residui di 200 μg\/kg per i muscoli.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eTEMPO DI SOSPENSIONE\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eMastite:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eCarne e frattaglie: 75 giorni.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eLatte: 13,5 giorni.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eInfezioni respiratorie:\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eCarne e frattaglie: 75 giorni.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eLatte: In caso di trattamento con dosi idonee per le infezioni respiratorie, il prodotto non è autorizzato per la somministrazione ad animali che producono latte destinato al consumo umano.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003ePRECAUZIONI PER L'USO NEGLI ANIMALI\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eNon somministrare più di 15 ml al bestiame in un unico sito.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eL'uso del prodotto deve essere basato su test di resistenza agli antibiotici di batteri isolati da animali. Se ciò non fosse possibile, la terapia dovrebbe basarsi su informazioni epidemiologiche locali (a livello regionale, di azienda agricola) sulla suscettibilità dei batteri bersaglio. L'uso del prodotto diverso dalle istruzioni riportate nel foglio illustrativo può aumentare la prevalenza della resistenza batterica alla spiramicina. Quando si utilizza il prodotto, è necessario tenere conto delle norme antimicrobiche ufficiali, nazionali e regionali.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003eLa mastite causata da S.aureus deve essere trattata solo dopo la comparsa dei segni clinici. Solo i casi acuti di mastite causata da S.aureus con segni clinici devono essere trattati e tenuti sotto osservazione per almeno 24 ore.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eUSO DURANTE LA GRAVIDANZA, L'ALLATTAMENTO O LA DOVE OVAI\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eNon sono stati segnalati effetti teratogeni nei topi. Dosi orali maternotossiche hanno causato embriotossicità nei conigli. La sicurezza del prodotto non è stata stabilita nelle mucche durante la gravidanza e l'allattamento. Tuttavia, l'uso del prodotto durante la gravidanza e l'allattamento non dovrebbe causare preoccupazioni tossicologiche. Studi di laboratorio su cani e ratti hanno evidenziato effetti sulla spermatogenesi quando si utilizzano dosi elevate pari a 2.050.000 UI\/kg di peso corporeo al giorno per 56 giorni. La sicurezza del prodotto nei maschi riproduttori non è stata stabilita. Nel caso di questi animali, l'uso del prodotto verrà effettuato dopo che il veterinario avrà valutato il rapporto beneficio\/rischio.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eSOVRADOSAGGIO\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003ePoiché la tossicità della spiramicina è bassa, un sovradosaggio non produce effetti tossici.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eINCOMPATIBILITÀ\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eIn assenza di studi di compatibilità, questo medicinale veterinario non deve essere miscelato con altri medicinali veterinari.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003ePROPRIETÀ FARMACODINAMICHE\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eLa spiramicina agisce sulla sintesi proteica batterica legandosi alla subunità ribosomiale 50S, inibendo la fase di traslocazione. La spiramicina è in grado di raggiungere elevate concentrazioni tissutali, riuscendo a penetrare intracellularmente e a legarsi alla subunità ribosomiale 50S.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eLe seguenti concentrazioni minime inibitorie (MIC) sono state determinate su ceppi europei isolati da animali malati tra il 2007 e il 2012:\u003c\/span\u003e\u003c\/p\u003e\n\u003ctable cellspacing=\"0\" cellpadding=\"0\" border=\"1\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd rowspan=\"2\"\u003e\n\u003cp\u003e\u003cspan\u003eSpecie batteriche\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd rowspan=\"2\"\u003e\n\u003cp\u003e\u003cspan\u003eOrigine\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd rowspan=\"2\"\u003e\n\u003cp\u003e\u003cspan\u003eNO. di steli\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd colspan=\"3\"\u003e\n\u003cp\u003e\u003cspan\u003eSpiramicina MIC (μg\/mL)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003eAllineare\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003eMicrofono \u003c\/span\u003e\u003csub\u003e\u003cspan\u003e50\u003c\/span\u003e\u003c\/sub\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003eCMI \u003c\/span\u003e\u003csub\u003e\u003cspan\u003e90\u003c\/span\u003e\u003c\/sub\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cem\u003e\u003cspan\u003ePasteurella multocida\u003c\/span\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003eBestiame\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e129\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e1- ≥512\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e16\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e32\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cem\u003e\u003cspan\u003eMannheimia emolitica\u003c\/span\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003eBestiame\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e149\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e4 - 512\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e64\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e128\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cem\u003e\u003cspan\u003eStafilococco aureo\u003c\/span\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003eBestiame\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e211\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e1 -≥64\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e4\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd\u003e\n\u003cp\u003e\u003cspan\u003e8\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eFARMACOCINETICA\u003c\/span\u003e\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003eDopo somministrazione intramuscolare, la spiramicina viene rapidamente assorbita e raggiunge le concentrazioni plasmatiche di picco entro tre ore. La spiramicina viene metabolizzata nel fegato e il suo metabolita principale, la neospiramicina, possiede attività antibatterica. Viene eliminato principalmente attraverso l'escrezione biliare.\u003c\/span\u003e\u003c\/p\u003e","brand":"Ceva Sante","offers":[{"title":"Default Title","offer_id":50197252473179,"sku":"","price":49.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0476\/3261\/3543\/files\/spirovet-100-ml_4494.webp?v=1741338322","url":"https:\/\/www.petshopluna.com\/en-at\/products\/spirovet-100ml-inj-spiramicina-cattle-pigs-bovini-e-suini","provider":"Pet Shop Maya","version":"1.0","type":"link"}