{"product_id":"credelio-antiparasitic-for-dogs-3-tablets","title":"CREDELIO- antiparasitic for dogs - 3 tablets","description":"For the treatment of flea and tick infestation in dogs.\u003cbr data-mce-fragment=\"1\"\u003eThe veterinary medicinal product has the activity of immediate and persistent elimination for up to a month of fleas (Ctenocephalides felis and C. canis) and ticks (Rhipicephalus sanguineus, Ixodes ricinus, I. hexagonus and Dermacentor reticulatus).\u003cbr data-mce-fragment=\"1\"\u003eFleas and ticks must attach to the host and begin to feed in order to be exposed to the active substance.\u003cbr data-mce-fragment=\"1\"\u003eThe veterinary medicinal product can be used as part of a therapeutic strategy in the control of allergic dermatitis caused by flea saliva.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eContraindications\u003cbr data-mce-fragment=\"1\"\u003eDo not use in case of hypersensitivity to the active substance or to any of the excipients.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe parasites must begin to feed in order to be exposed to the lotilaner; Consequently, the risk of transmission of diseases through parasites cannot be completely ruled out.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eAll safety and efficacy data were obtained after administration to dogs and puppies aged at least 8 weeks and with a body weight of at least 1.3 kg. The decision to use this veterinary medicinal product in puppies under 8 weeks of age or with a body weight of less than 1.3 kg must be made on the basis of the risk \/ benefit assessment carried out by the responsible veterinarian.\u003cbr data-mce-fragment=\"1\"\u003eSpecial precautions to be taken by the person administering the veterinary medicinal product to animals Wash hands after handling the product.\u003cbr data-mce-fragment=\"1\"\u003eIn case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician.\u003cbr data-mce-fragment=\"1\"\u003eSide effects (frequency and severity)\u003cbr data-mce-fragment=\"1\"\u003eVery rarely, mild and transient gastrointestinal effects such as vomiting and diarrhea have been reported based on post-marketing experience. These signs usually go away without treatment.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eThe frequency of adverse reactions is defined using the following convention:\u003cbr data-mce-fragment=\"1\"\u003e- Very common (more than 1 in 10 treated animals with side effects)\u003cbr data-mce-fragment=\"1\"\u003e- Common (more than 1 but less than 10 animals out of 100 treated animals)\u003cbr data-mce-fragment=\"1\"\u003e- Uncommon (more than 1 but less than 10 animals per 1000 animals treated)\u003cbr data-mce-fragment=\"1\"\u003e- Rare (more than 1 but less than 10 animals out of 10 000 treated animals)\u003cbr data-mce-fragment=\"1\"\u003e- Very rare (less than 1 in 10,000 animals treated, including isolated reports).\u003cbr data-mce-fragment=\"1\"\u003eUse during pregnancy, lactation or lay. Laboratory studies in rats did not produce any evidence of teratogenic effects or any other adverse effects on reproductive capacity in males and females. The safety of the veterinary medicinal product has not been established in pregnant or lactating dogs or in breeding dogs. Use only in accordance with the risk \/ benefit assessment performed by the responsible veterinarian.\u003cbr data-mce-fragment=\"1\"\u003eInteractions with other medicinal products or other forms of interaction\u003cbr data-mce-fragment=\"1\"\u003eThey don't know each other. During clinical trials, no interactions were observed between Credelio chewable tablets for dogs and routine veterinary medicinal products.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eLotilaner, a pure enantiomer of the isoxazoline class, is active against fleas (Ctenocephalides felis and Ctenocephalides canis), as well as against the tick species Dermacentor reticulatus, Ixodes hexagonus, Ixodes ricinus, Rhipicephalus sanguineus.\u003cbr data-mce-fragment=\"1\"\u003eLotilaner is a potent inhibitor of chlorine ion channels regulated by gamma-aminobutyric acid (GABA), causing the rapid death of ticks and fleas. Lotilaner activity was not affected by resistance to organochlorine compounds (eg cyclodiene, dieldrin), phenylpyrazoles (eg fipronil), neonicotinoids (eg imidacloprid), formamidines (eg amitraz) and pyrethroids (eg cypermethrin). ).\u003cbr data-mce-fragment=\"1\"\u003eFor fleas, the installation of efficacy occurs within 4 hours of fixation and lasts one month after administration of the product. Fleas existing on the animal before administration are eliminated within 6 hours.\u003cbr data-mce-fragment=\"1\"\u003eFor ticks, the installation of efficacy occurs within 48 hours of fixation and lasts one month after administration of the product. Ticks (I. ricinus) existing on the animal before administration are removed within 8 hours.\u003cbr data-mce-fragment=\"1\"\u003eThe veterinary medicinal product removes fleas that exist on animals and have recently hatched before they can lay eggs. Therefore, the product interrupts the life cycle of fleas and prevents contamination of the environment with fleas in areas where dogs have access.\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003eAfter oral administration, lotilaner is absorbed immediately and the maximum plasma concentration is reached in 2 hours. Food intensifies absorption. The half-life until elimination is about 4 weeks. This long half-life until elimination ensures effective plasma concentrations over the entire dose interval.\u003cbr data-mce-fragment=\"1\"\u003eThe main route of elimination is by biliary excretion, renal excretion being the secondary route of elimination (less than 10% of the dose). Lotilaner is metabolysed to a small extent in several hydrophilic compounds that can be detected in feces and urine.","brand":"ELANCO","offers":[{"title":"112.5mg 2.5-5kg","offer_id":42121298313429,"sku":"","price":43.99,"currency_code":"EUR","in_stock":true},{"title":"225mg 5.5-11kg","offer_id":42121298346197,"sku":"","price":46.99,"currency_code":"EUR","in_stock":true},{"title":"450mg 11-22kg","offer_id":42121298378965,"sku":"","price":49.99,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0476\/3261\/3543\/products\/credelio.png?v=1637867130","url":"https:\/\/www.petshopluna.com\/en-at\/products\/credelio-antiparasitic-for-dogs-3-tablets","provider":"Pet Shop Maya","version":"1.0","type":"link"}